Some new 2,5-disubstituted-1,3,4-oxadiazole derivatives of Naproxen were synthesized by reaction of 2-(6-methoxynaphthalen-2-yl) propanehydrazide and various aromatic acids in the presence of phosphorus oxychloride. The structure were verified on the basis of satisfactory analytical and spectral (IR, (1) H NMR, MS) data. The newly synthesized compounds were evaluated for their in-vivo anti-inflammatory and analgesic activities as per standard protocols. Above study showed that some newly synthesized compounds possess significant analgesic and anti-inflammatory activities.
Loading....